Anti-FKBP5 Polyclonal Antibody (HC679014)

Name: Anti-FKBP5 Polyclonal Antibody
Brand: abinScience
SKU: HC679014
Price: 96 USD
Availability: InStock

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Overview

Catalog No.

HC679014

Species reactivity

Human, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human FKBP5 (Ser13-Lys252).

Target

AIG6, 51 kDa FKBP, FKBP51, FKBP54, Rotamase, Peptidyl-prolyl cis-trans isomerase FKBP5, FF1 antigen, 51 kDa FK506-binding protein, FKBP-51, Androgen-regulated protein 6, p54, PPIase FKBP5, 54 kDa progesterone receptor-associated immunophilin, HSP90-binding immunophilin, FKBP-5, FK506-binding protein 5, FKBP5

Purification

Purified by antigen affinity column.

Accession

Q13451

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Peptidyl-prolyl cis-trans isomerase FKBP5 is a ~51 kDa protein. Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production.

1. Pirkl, F. et al. (2001) Journal of molecular biology 308, 795-806. PMID: 11350175

2. Sinars, CR. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 868-73. PMID: 12538866

3. Yu, J. et al. (2017) Cell reports 18, 1229-1240. PMID: 28147277

4. Luo, K. et al. (2017) The EMBO journal 36, 1434-1446. PMID: 28363942

5. Romano, S. et al. (2015) Nucleic acids research 43, 6983-93. PMID: 26101251

6. DeDiego, ML. et al. (2019) Journal of virology 93. PMID: 31434731

Note

For research use only.

Images

References

Datasheet

Anti-FKBP5 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-FKBP5 Polyclonal Antibody (HC679014)

Overview

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References

Datasheet

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