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Anti-FOXK1 Polyclonal Antibody (HB309014)

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Overview
Catalog No.HB309014
Description
Anti-FOXK1 Polyclonal Antibody (HB309014) is a rabbit polyclonal antibody detecting Forkhead box protein K1; Myocyte nuclear factor; MNF; FOXK1; MNF in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant human FOXK1 (Ala86-Arg395).
Target Forkhead box protein K1; Myocyte nuclear factor; MNF; FOXK1; MNF
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P85037, P42128
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Forkhead box protein K1 (FOXK1) is a ~75 kDa protein. Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy. Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context. Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen. Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4. Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate.

1. Freddie, CT. et al. (2007) Nucleic acids research 35, 5203-12. PMID: 17670796
2. Wang, W. et al. (2015) Developmental cell 32, 707-18. PMID: 25805136
3. Panda, D. et al. (2015) mBio 6. PMID: 25852164
4. Baymaz, HI. et al. (2014) Proteomics 14, 2179-89. PMID: 24634419
5. Campagne, A. et al. (2019) Nature communications 10, 348. PMID: 30664650
6. Zhang, HL. et al. (2025) Nature chemical biology 21, 1531-1543. PMID: 40246981
Note For research use only
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Formula
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Anti-FOXK1 Polyclonal Antibody

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