Anti-FURIN Polyclonal Antibody (HY484014)

Name: Anti-FURIN Polyclonal Antibody
Brand: abinScience
SKU: HY484014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HY484014

Description

Anti-FURIN Polyclonal Antibody (HY484014) is a rabbit polyclonal antibody detecting FURIN in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human FURIN (Thr105-Ile221).

Target

FUR, PCSK3, PACE, FURIN, Dibasic-processing enzyme, Paired basic amino acid residue-cleaving enzyme, Furin

Purification

Purified by antigen affinity column.

Accession

P09958

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Furin is a ~86 kDa protein. Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32). By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells.

1. Anderson, ED. et al. (2002) The Journal of biological chemistry 277, 12879-90. PMID: 11799113

2. Leduc, R. et al. (1992) The Journal of biological chemistry 267, 14304-8. PMID: 1629222

3. Barr, PJ. et al. (1991) DNA and cell biology 10, 319-28. PMID: 1713771

4. Wise, RJ. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 9378-82. PMID: 2251280

5. Dahms, SO. et al. (2014) ACS chemical biology 9, 1113-8. PMID: 24666235

6. Hardes, K. et al. (2015) ChemMedChem 10, 1218-31. PMID: 25974265

7. Takahashi, S. et al. (1995) The Journal of biological chemistry 270, 26565-9. PMID: 7592877

8. Takahashi, S. et al. (1993) Biochemical and biophysical research communications 195, 1019-26. PMID: 7690548

9. Anderson, ED. et al. (1997) The EMBO journal 16, 1508-18. PMID: 9130696

10. Dubois, CM. et al. (1995) The Journal of biological chemistry 270, 10618-24. PMID: 7737999

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-FURIN polyclonal antibody at 1ug/mL on recombinant FURIN (Catalog No. HY484012).

References

Datasheet

Anti-FURIN Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-FURIN Polyclonal Antibody (HY484014)

Overview

Images

References

Datasheet

SDS

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