Anti-GABRA2 Polyclonal Antibody (HW333014)

Name: Anti-GABRA2 Polyclonal Antibody
Brand: abinScience
SKU: HW333014
Price: 168 USD
Availability: InStock

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Overview
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SDS

Overview

Catalog No.

HW333014

Description

Anti-GABRA2 Polyclonal Antibody (HW333014) is a rabbit polyclonal antibody detecting GABRA2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human GABRA2 (Phe42-Ile250).

Target

GABA(A) receptor subunit alpha-2, GABRA2, Gamma-aminobutyric acid receptor subunit alpha-2

Purification

Purified by antigen affinity column.

Accession

P47869

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2) is a ~51 kDa protein. Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces. When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. The alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation.

1. Bonnert, TP. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 9891-6. PMID: 10449790

2. Butler, KM. et al. (2018) Brain : a journal of neurology 141, 2392-2405. PMID: 29961870

3. Maljevic, S. et al. (2019) Brain : a journal of neurology 142, e15. PMID: 31032849

Note

For research use only.

Images

References

Datasheet

Anti-GABRA2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-GABRA2 Polyclonal Antibody (HW333014)

Overview

Images

References

Datasheet

SDS

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