Anti-GGT5 Polyclonal Antibody (HW691014)

Name: Anti-GGT5 Polyclonal Antibody
Brand: abinScience
SKU: HW691014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HW691014

Description

Anti-GGT5 Polyclonal Antibody (HW691014) is a rabbit polyclonal antibody detecting GGT5 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human GGT5 (Thr388-Tyr586).

Target

GGTLA1, Gamma-glutamyl transpeptidase-related enzyme, Gamma-glutamyltranspeptidase 5, Glutathione hydrolase 5 proenzyme, GGT 5, Gamma-glutamyltransferase 5, GGT5, Leukotriene-C4 hydrolase, Gamma-glutamyltransferase-like activity 1, GGT-rel

Purification

Purified by antigen affinity column.

Accession

P36269

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Glutathione hydrolase 5 proenzyme (GGT5) is a ~62 kDa protein. Cleaves the gamma-glutamyl bond of extracellular glutathione tripeptide (gamma-Glu-Cys-Gly) and certain glutathione conjugates. Hydrolyzes glutathione releasing L-Glu and Cys-Gly dipeptide which is further metabolized to maintain extracellular cysteine levels but also to provide cysteine necessary for intracellular glutathione synthesis. Among glutathione-S-conjugates metabolizes leukotriene C4 (LTC4) and S-geranylgeranyl-glutathione (GGG), but is inactive toward gamma-glutamyl leucine. Converts extracellular LTC4 to LTD4 during acute inflammatory response. Acts as a negative regulator of GGG bioactivity.

1. Heisterkamp, N. et al. (1991) Proceedings of the National Academy of Sciences of the United States of America 88, 6303-7. PMID: 1676842

2. Wickham, S. et al. (2011) Analytical biochemistry 414, 208-14. PMID: 21447318

3. Bachhawat, AK. et al. (2018) IUBMB life 70, 585-592. PMID: 29667297

Note

For research use only.

Images

References

Datasheet

Anti-GGT5 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-GGT5 Polyclonal Antibody (HW691014)

Overview

Images

References

Datasheet

SDS

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