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Anti-GNA13 Polyclonal Antibody (HB520014)

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Overview
Catalog No.HB520014
Description
Anti-GNA13 Polyclonal Antibody (HB520014) is a rabbit polyclonal antibody detecting Guanine nucleotide-binding protein subunit alpha-13; G alpha-13; G-protein subunit alpha-13; GNA13 in ELISA, IHC, WB. Suitable for Human, Rat, and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant human GNA13 (Leu48-Gln377).
Target Guanine nucleotide-binding protein subunit alpha-13; G alpha-13; G-protein subunit alpha-13; GNA13
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q14344, Q6Q7Y5, P27601
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Guanine nucleotide-binding protein subunit alpha-13 (GNA13) is a ~44 kDa protein. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway. Inhibits CDH1-mediated cell adhesion in a process independent from Rho activation.

1. Krakstad, BF. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 10314-9. PMID: 15240885
2. Kelly, P. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 8173-8. PMID: 16705036
3. Kelly, P. et al. (2006) The Journal of biological chemistry 281, 26483-90. PMID: 16787920
4. Yuan, B. et al. (2016) Biochemical and biophysical research communications 473, 1240-1246. PMID: 27084452
5. Suzuki, N. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 733-8. PMID: 12515866
6. Meigs, TE. et al. (2002) The Journal of biological chemistry 277, 24594-600. PMID: 11976333
Note For research use only
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Formula
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Anti-GNA13 Polyclonal Antibody

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