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Anti-GPR4 Polyclonal Antibody (HA696014)

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Overview
Catalog No.HA696014
Description
Anti-GPR4 Polyclonal Antibody (HA696014) is a rabbit polyclonal antibody detecting G-protein coupled receptor 4; G-protein coupled receptor 6C.l; GPR6C.l; GPR4 in ELISA, IHC, WB. Suitable for Human, Bovine, and Pig.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant human GPR4 (Ile284-Gln362).
Target G-protein coupled receptor 4; G-protein coupled receptor 6C.l; GPR6C.l; GPR4
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P46093, Q1JQB3, P50132
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

G-protein coupled receptor 4 (GPR4) is a ~40 kDa protein. Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions. Activated by an optimal pH of 6.8-7.2. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. GPR4 is mainly coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. May also couple with G(i), G(q) and G(12)/G(13) G proteins.

1. Ludwig, MG. et al. (2003) Nature 425, 93-8. PMID: 12955148
2. Tobo, M. et al. (2007) Cellular signalling 19, 1745-53. PMID: 17462861
3. Rowe, JB. et al. (2021) The Journal of biological chemistry 296, 100167. PMID: 33478938
4. Howard, MK. et al. (2025) Cell 188, 671-687.e20. PMID: 39753132
5. Ma, Y. et al. (2025) Nature communications 16, 605. PMID: 39799123
6. Yue, X. et al. (2025) Cell research 35, 423-436. PMID: 40211064
7. Guo, L. et al. (2025) Molecular cell 85, 1658-1673.e7. PMID: 40215959
8. Chen, LN. et al. (2025) Molecular cell 85, 1640-1657.e8. PMID: 40215960
Note For research use only
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Datasheet
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Formula
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Anti-GPR4 Polyclonal Antibody

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