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Anti-GZMK Polyclonal Antibody (HW458014)

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Overview
Catalog No.HW458014
Description
Anti-GZMK Polyclonal Antibody (HW458014) is a rabbit polyclonal antibody detecting GZMK in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human GZMK (Ile27-Asn264).
Target NK-tryptase-2, Fragmentin-3, Granzyme K, GZMK, Granzyme-3, TRYP2, NK-Tryp-2
Purification Purified by antigen affinity column.
Accession P49863
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Granzyme K (GZMK) is a ~28 kDa protein. Serine protease that initiates the GZMK pathway of the complement system, a cascade of proteins directly activated by CD8(+) T-cells that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. GZMK is specifically secreted by CD8(+) T-cells and mediates both recognition and initiation steps of GZMK complement pathway. First acts as a pattern recognition receptor, which specifically recognizes and binds heparan sulfate glycosaminoglycans on the pathogen surface to drive opsonization. It then initiates the complement pathway cascade by catalyzing cleavage and activation of C2 and C4, the next components of the complement pathway. GZMK-mediated complement activation is an important contributor to tissue inflammation.

1. Hameed, A. et al. (1988) Journal of immunology (Baltimore, Md. : 1950) 141, 3142-7. PMID: 3262682
2. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882
3. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456
4. Wensink, AC. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 5974-9. PMID: 24711407
5. Mogilenko, DA. et al. (2021) Immunity 54, 99-115.e12. PMID: 33271118
6. Jonsson, AH. et al. (2022) Science translational medicine 14, eabo0686. PMID: 35704599
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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V₁ (Stock Vol.)
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C₂ (Working Conc.)
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Anti-GZMK Polyclonal Antibody

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