Anti-HCMV/HHV5 HHRF3/US28 Recombinant Nanobody (SAA0899) (VK595023)

Name: Anti-HCMV/HHV5 HHRF3/US28 Recombinant Nanobody (SAA0899)
Brand: abinScience
SKU: VK595023
Price: 126 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

VK595023

Description

Anti-HCMV/HHV5 HHRF3/US28 Nanobody (SAA0899) [SAA0899] (VK595023) is a alpaca monoclonal antibody detecting HHRF3 in ELISA.

Species reactivity

Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Applications

ELISA

Host species

Alpaca

Isotype

VHH-8His-Cys-tag

Clone ID

SAA0899

Clonality

Monoclonal

Target

G-protein coupled receptor homolog US28, HHRF3, US28

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column.

Accession

P69333

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

G-protein coupled receptor homolog US28 (HHRF3) is a ~41 kDa protein. Viral chemokine receptor that plays a critical role in viral pathogenesis, mediating several processes such as cellular migration, differentiation, transformation, and viral latency and reactivation. Binds to a great number of different CC-chemokines including CCL5/RANTES, CCL2/MCP-1, CCL3/MIP-1-alpha as well as CX3CL1/Fractalkine. Transduces signals resulting in the activation of MAP kinase signaling pathways and augmentation of intracellular calcium ion levels, leading to alterations in chemotactic behavior of vascular smooth muscle cells and macrophages. The US28 receptor also exhibits high levels of agonist-independent signaling activity and agonist-independent endocytosis. Interacts with the host Gi complex without activating it, thereby probably interfering with the chemokine-Gi signaling.

1. Miles, TF. et al. (2018) eLife 7. PMID: 29882741

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-HCMV/HHV5 HHRF3/US28 Nanobody (SAA0899).

References

Datasheet

Anti-HCMV/HHV5 HHRF3/US28 Recombinant Nanobody (SAA0899).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-HCMV/HHV5 HHRF3/US28 Recombinant Nanobody (SAA0899) (VK595023)

Overview

Images

References

Datasheet

SDS

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