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Anti-HDAC8 Polyclonal Antibody (HV385014)

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Overview
Catalog No.HV385014
Description
Anti-HDAC8 Polyclonal Antibody (HV385014) is a rabbit polyclonal antibody detecting HDAC8 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human HDAC8 (Met1-Val377).
Target HDAC8, Histone deacetylase 8, HD8, HDACL1
Purification Purified by antigen affinity column.
Accession Q9BY41
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Histone deacetylase 8 (HDAC8) is a ~41 kDa protein. Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.

1. Hu, E. et al. (2000) The Journal of biological chemistry 275, 15254-64. PMID: 10748112
2. Van den Wyngaert, I. et al. (2000) FEBS letters 478, 77-83. PMID: 10922473
3. Buggy, JJ. et al. (2000) The Biochemical journal 350 Pt 1, 199-205. PMID: 10926844
4. Lee, H. et al. (2004) Molecular and cellular biology 24, 765-73. PMID: 14701748
5. Wei, W. et al. (2017) Cell research 27, 898-915. PMID: 28497810
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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V₁ (Stock Vol.)
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Working Solution
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Anti-HDAC8 Polyclonal Antibody

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