

| Catalog No. | VK620073 |
|---|---|
| Description |
Anti-Hepatitis E virus/HEV ORF3 Antibody (SAA2695) [SAA2695] (VK620073) is a human monoclonal antibody detecting Protein ORF3 in ELISA, IF, WB.
Highlights
|
| Species reactivity | Hepatitis E virus (HEV) |
| Applications | ELISA, IF, WB |
| Host species | Human |
| Isotype | IgG1 |
| Clone ID | SAA2695 |
| Clonality | Monoclonal |
| Target | Protein ORF3 |
| Endotoxin level | <10 EU/mg |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Accession | E9N3C1 |
| Form | Liquid |
| Storage buffer | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Background | Protein ORF3 is a ~11 kDa protein. Small multifunctional phosphoprotein involved in virion morphogenesis, egress and counteracting host innate immunity. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. Also acts as a viroporin and forms ion conductive pores allowing viral particle release. Impairs the generation of type I interferon by down-regulating host TLR3 and TLR7 as well as their downstream signaling pathways. Down-regulates the phosphorylation of host IRF3 via the interaction with host SIRP-alpha, thereby inhibiting IFN-I expression. |
| Note | For research use only |
Contact us for custom quotes, bulk requests and any other issues.
Mail: support@abinScience.com
+86-27-65523339
Building C, No. 666, Shen Dun Si Lu, Wuhan, 430206, China
中文
English
한국어
日本語
Español
Français
Русский