Anti-HNRNPA2B1 Polyclonal Antibody (HB093014)

Name: Anti-HNRNPA2B1 Polyclonal Antibody
Brand: abinScience
SKU: HB093014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HB093014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human HNRNPA2B1 (Arg21-Gly103).

Target

Heterogeneous nuclear ribonucleoproteins A2/B1, HNRPA2B1, hnRNP A2/B1, HNRNPA2B1

Purification

Purified by antigen affinity column.

Accession

P22626

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) is a ~37 kDa protein. Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm.

1. He, Y. et al. (2009) Cellular and molecular life sciences : CMLS 66, 1239-56. PMID: 19099192

2. Munro, TP. et al. (1999) The Journal of biological chemistry 274, 34389-95. PMID: 10567417

3. Alarcón, CR. et al. (2015) Cell 162, 1299-308. PMID: 26321680

4. Villarroya-Beltri, C. et al. (2013) Nature communications 4, 2980. PMID: 24356509

5. David, CJ. et al. (2010) Nature 463, 364-8. PMID: 20010808

6. Wang, L. et al. (2019) Science (New York, N.Y.) 365. PMID: 31320558

Note

For research use only.

Images

References

Datasheet

Anti-HNRNPA2B1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-HNRNPA2B1 Polyclonal Antibody (HB093014)

Overview

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Datasheet

SDS

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