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Anti-HPIV3 prefusion F trimer Antibody (SAA2729) (VK007073)

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Overview

Catalog No.	VK007073
Description	Anti-HPIV3 prefusion F trimer Antibody (SAA2729) [SAA2729] (VK007073) is a human monoclonal antibody detecting HPIV3 prefusion F trimer in ELISA, Neutralization.
Species reactivity	Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))
Applications	ELISA, Neutralization
Host species	Human
Isotype	IgG1, kappa
Clone ID	SAA2729
Clonality	Monoclonal
Target	F, Fusion glycoprotein F0, Fusion glycoprotein F1, Fusion glycoprotein F2
Endotoxin level	<10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P06828
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Fusion glycoprotein F0 is a ~60 kDa protein. Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm.
Note	For research use only

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Datasheet

Anti-HPIV3 prefusion F trimer Antibody (SAA2729).pdf

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Anti-HPIV3 prefusion F trimer Antibody (SAA2729)