Anti-HPV18 E7/Protein E7 Recombinant Antibody (SAA2229) (VK556063)

Name: Anti-HPV18 E7/Protein E7 Recombinant Antibody (SAA2229)
Brand: abinScience
SKU: VK556063
Price: 126 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

VK556063

Species reactivity

Human papillomavirus 16 (HPV16), Human papillomavirus 18 (HPV18)

Applications

ELISA, IP, WB, ICC, IHC

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA2229

Expression system

Mammalian cells

Clonality

Monoclonal

Target

Endotoxin level

<10 EU/mg

Purity

>95% purity as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P06788

RRID

Anti-HPV18 E7/Protein E7 Antibody (SAA2229) (abinScience Cat# VK556063, RRID:AB_3729825)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

Alternate Names

Protein E7, E7

Background

Protein E7 is a ~11 kDa protein. Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.

1. Lau, L. et al. (2015) Science (New York, N.Y.) 350, 568-71. PMID: 26405230

Note

For research use only.

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