Anti-HTR1A Polyclonal Antibody (MY581014)

Name: Anti-HTR1A Polyclonal Antibody
Brand: abinScience
SKU: MY581014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

MY581014

Description

Anti-HTR1A Polyclonal Antibody (MY581014) is a rabbit polyclonal antibody detecting 5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; Serotonin receptor 1A; Htr1a; Gpcr18 in ELISA, IHC, WB. Suitable for Mouse and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant mouse HTR1A (Ile218-Lys345).

Target

5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; Serotonin receptor 1A; Htr1a; Gpcr18

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q64264, P19327

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

5-hydroxytryptamine receptor 1A (HTR1A) is a ~46 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes.

1. Ase, AR. et al. (2000) Journal of neurochemistry 75, 2415-26. PMID: 11080193

2. Deng, DR. et al. (2007) Neuroscience 147, 388-402. PMID: 17543467

3. Audero, E. et al. (2008) Science (New York, N.Y.) 321, 130-3. PMID: 18599790

4. Richardson-Jones, JW. et al. (2011) The Journal of neuroscience : the official journal of the Society for Neuroscience 31, 6008-18. PMID: 21508226

5. Charest, A. et al. (1993) The Journal of neuroscience : the official journal of the Society for Neuroscience 13, 5164-71. PMID: 8254366

6. Ramboz, S. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 14476-81. PMID: 9826725

Note

For research use only

Images

References

Datasheet

Anti-HTR1A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-HTR1A Polyclonal Antibody (MY581014)

Overview

Images

References

Datasheet

SDS

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