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Anti-Human A2ML1 Polyclonal Antibody (HT462014)

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Overview
Catalog No.HT462014
Description
Anti-Human A2ML1 Polyclonal Antibody (HT462014) is a rabbit polyclonal antibody detecting A2ML1. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human A2ML1 (Val946-Met1257).
Target A2ML1, Alpha-2-macroglobulin-like protein 1, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9, CPAMD9
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession A8K2U0
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Alpha-2-macroglobulin-like protein 1 (A2ML1) is a ~161 kDa protein. Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Note For research use only
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Anti-Human A2ML1 Polyclonal Antibody

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