Anti-Human ACADSB Polyclonal Antibody (HW543014)

Name: Anti-Human ACADSB Polyclonal Antibody
Brand: abinScience
SKU: HW543014
Price: 96 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HW543014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human ACADSB (Thr58-Tyr432).

Target

2-methyl branched chain acyl-CoA dehydrogenase, SBCAD, 2-MEBCAD, 2-methylbutyryl-CoA dehydrogenase, ACADSB, Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial, 2-methylbutyryl-coenzyme A dehydrogenase

Purification

Purified by antigen affinity column.

Accession

P45954

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (ACADSB) is a ~47 kDa protein. Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (butanoyl-CoA). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway. Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug.

1. Gibson, KM. et al. (2000) Pediatric research 47, 830-3. PMID: 10832746

2. Andresen, BS. et al. (2000) American journal of human genetics 67, 1095-103. PMID: 11013134

3. Luís, PB. et al. (2011) Drug metabolism and disposition: the biological fate of chemicals 39, 1155-60. PMID: 21430231

4. Rozen, R. et al. (1994) Genomics 24, 280-7. PMID: 7698750

Note

For research use only.

Images

References

Datasheet

Anti-Human ACADSB Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-Human ACADSB Polyclonal Antibody (HW543014)

Overview

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References

Datasheet

SDS

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