

| Catalog No. | HC227014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human ACADVL Polyclonal Antibody (HC227014) is a rabbit polyclonal antibody detecting ACADVL. Suitable for Human.
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| Species reactivity | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human ACADVL (Glu96-Phe655). | ||||||||
| Target | ACADVL, EC:1.3.8.9, VLCAD, Very long-chain specific acyl-CoA dehydrogenase, mitochondrial | ||||||||
| Endotoxin level | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | P49748 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Background | Very long-chain acyl-CoA dehydrogenase, mitochondrial (ACADVL) is a ~70 kDa protein. Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on fatty acyl-CoAs with saturated 12 to 24 carbons long primary chains. 1. He, M. et al. (2007) American journal of human genetics 81, 87-103. PMID: 17564966 2. McAndrew, RP. et al. (2008) The Journal of biological chemistry 283, 9435-43. PMID: 18227065 3. Aoyama, T. et al. (1995) American journal of human genetics 57, 273-83. PMID: 7668252 4. Souri, M. et al. (1998) The Journal of biological chemistry 273, 4227-31. PMID: 9461620 5. Souri, M. et al. (1998) FEBS letters 426, 187-90. PMID: 9599005 6. Souri, M. et al. (1998) European journal of biochemistry 257, 592-8. PMID: 9839948 7. He, M. et al. (2011) Molecular genetics and metabolism 102, 418-29. PMID: 21237683 | ||||||||
| Note | For research use only |
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