Anti-Human Activin RIIA/B Recombinant Antibody (SAA0125), PerCP (HB949147)

Name: Anti-Human Activin RIIA/B Recombinant Antibody (SAA0125), PerCP
Brand: abinScience
SKU: HB949147
Price: 268 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD): --

Spec:

50T
100T

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.	HB949147
Description	Anti-Human Activin RIIA/B Recombinant Antibody (SAA0125), PerCP (HB949147) is a human monoclonal antibody detecting Activin RIIA,Activin RIIB in FCM. Suitable for Human. Highlights ●PerCP Conjugated — Ready for direct detection without secondary antibody.
Species reactivity	Human
Applications	FCM
Host species	Human
Clonality	Monoclonal
Isotype	IgG1, lambda
Clone ID	SAA0125
Conjugation	PerCP
Expression system	Mammalian cells
Nature	Recombinant
Target	ACVR2, ACTRIIA, ACTR-IIA, Activin receptor type IIA, ACVR2A, Activin receptor type-2A, ACTR-IIB, Activin receptor type IIB, Activin receptor type-2B, ACVR2B
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Associated products	Human IgG1 lambda Isotype Control Antibody (HyHEL-10), PerCP
Accession	P27037 & Q13705
Form	Liquid
Storage buffer	0.01M PBS pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Bimagrumab is a monoclonal anti-ActRIIA/IIB antibody that targets ActRIIA and ActRIIB simultaneously. Native ActRIIA and ActRIIB are both mediators of signaling from several TGFβ superfamily members such as activins, myostatin, and GDF11. Hence, pan-blockade by Bimagrumab achieves greater effect than a monoclonal antibody against either receptor alone, i.e. monotherapy with anti-ActRIIA antibody or anti-ActRIIB antibody. Bimagrumab has been explored as a therapy for sporadic inclusion body myositis, primary sarcopenia, and muscle wasting associated with chronic obstructive pulmonary disease. • Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B., PMID:26047946 • BMPR2 inhibits activin and BMP signaling via wild-type ALK2., PMID:29739878 • ALK2/ALK3-BMPR2/ACVR2A Mediate BMP2-Induced Downregulation of Pentraxin 3 Expression in Human Granulosa-Lutein Cells., PMID:28977600 • Follicular localization of growth differentiation factor 8 and its receptors in normal and polycystic ovary syndrome ovaries., PMID:29409020
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

Images

References

Datasheet

Anti-Human Activin RIIA/B Recombinant Antibody (SAA0125), PerCP.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human Activin RIIA/B Recombinant Antibody (SAA0125), PerCP (HB949147)

Overview

Images

References

Datasheet

SDS