Anti-Human ADAMTS4 Recombinant Antibody (4D8) (HF893013)

Name: Anti-Human ADAMTS4 Recombinant Antibody (4D8)
Brand: abinScience
SKU: HF893013
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HF893013

Species reactivity

Human

Applications

ELISA, Neutralization

Host species

Mouse

Isotype

IgG1

Clone ID

4D8

Clonality

Monoclonal

Target

ADAMTS4, A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, ADMP-1, Aggrecanase-1

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O75173

RRID

Anti-Human ADAMTS4 Antibody (4D8) (abinScience Cat# HF893013, RRID:AB_3725377)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) is a ~90 kDa protein. Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover. Also cleaves COMP. May play an important role in the destruction of aggrecan in arthritic diseases. Could be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease.

1. Tortorella, MD. et al. (1999) Science (New York, N.Y.) 284, 1664-6. PMID: 10356395

2. Tortorella, M. et al. (2000) The Journal of biological chemistry 275, 25791-7. PMID: 10827174

3. de Groot, R. et al. (2025) Matrix biology : journal of the International Society for Matrix Biology 135, 106-124. PMID: 39672391

Note

For research use only.

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