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Anti-Human ALKBH2 Polyclonal Antibody (HD328014)

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Overview
Catalog No.HD328014
Description
Anti-Human ALKBH2 Polyclonal Antibody (HD328014) is a rabbit polyclonal antibody detecting ALKBH2. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human ALKBH2 (Ser56-Lys261).
Target ABH2, ALKBH2, Alkylated DNA repair protein alkB homolog 2, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, DNA oxidative demethylase ALKBH2, EC:1.14.11.33, Oxy DC1
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q6NS38
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

DNA oxidative demethylase ALKBH2 is a ~29 kDa protein. Dioxygenase that repairs alkylated nucleic acid bases by direct reversal oxidative dealkylation. Can process both double-stranded (ds) and single-stranded (ss) DNA substrates, with a strong preference for dsDNA. Uses molecular oxygen, 2-oxoglutarate and iron as cofactors to oxidize the alkyl groups that are subsequently released as aldehydes, regenerating the undamaged bases. Probes the base pair stability, locates a weakened base pair and flips the damaged base to accommodate the lesion in its active site for efficient catalysis. Repairs monoalkylated bases, specifically N1-methyladenine and N3-methylcytosine, as well as higher order alkyl adducts such as bases modified with exocyclic bridged adducts known as etheno adducts including 1,N6-ethenoadenine, 3,N4-ethenocytosine and 1,N2-ethenoguanine.

1. Duncan, T. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 16660-5. PMID: 12486230
2. Aas, PA. et al. (2003) Nature 421, 859-63. PMID: 12594517
3. Lee, DH. et al. (2005) The Journal of biological chemistry 280, 39448-59. PMID: 16174769
4. Chen, B. et al. (2010) Molecular bioSystems 6, 2143-9. PMID: 20714506
5. Li, P. et al. (2013) Cell reports 4, 817-29. PMID: 23972994
6. Zdżalik, D. et al. (2015) DNA repair 30, 1-10. PMID: 25797601
7. Yang, CG. et al. (2008) Nature 452, 961-5. PMID: 18432238
8. Yi, C. et al. (2012) Nature structural & molecular biology 19, 671-6. PMID: 22659876
Note For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human ALKBH2 Polyclonal Antibody

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