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Anti-Human ALKBH5 Polyclonal Antibody (HA341014)

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Overview
Catalog No.HA341014
Description
Anti-Human ALKBH5 Polyclonal Antibody (HA341014) is a rabbit polyclonal antibody detecting ALKBH5 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human ALKBH5 (Met1-His394).
Target ALKBH5, ABH5, OFOXD1, RNA demethylase ALKBH5, Alkylated DNA repair protein alkB homolog 5, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5
Purification Purified by antigen affinity column.
Accession Q6P6C2
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

RNA demethylase ALKBH5 is a ~44 kDa protein. Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Demethylates RNA by oxidative demethylation, which requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing, translation and export. Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells.

1. Zheng, G. et al. (2013) Molecular cell 49, 18-29. PMID: 23177736
2. Aik, W. et al. (2014) Nucleic acids research 42, 4741-54. PMID: 24489119
3. Feng, C. et al. (2014) The Journal of biological chemistry 289, 11571-11583. PMID: 24616105
4. Xu, C. et al. (2014) The Journal of biological chemistry 289, 17299-311. PMID: 24778178
5. Yu, F. et al. (2021) Nucleic acids research 49, 5779-5797. PMID: 34048572
6. Cieśla, M. et al. (2023) Molecular cell 83, 1165-1179.e11. PMID: 36944332
7. Yu, F. et al. (2023) Molecular cell 83, 2003-2019.e6. PMID: 37257451
8. Zhang, XL. et al. (2023) Nature communications 14, 3815. PMID: 37369679
9. Sun, H-Y. et al. (2025) Journal of virology 99, e0050725. PMID: 40793791
10. Thalhammer, A. et al. (2011) PloS one 6, e16210. PMID: 21264265
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human ALKBH5 Polyclonal Antibody

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