Anti-Human ASIC1 Polyclonal Antibody (HX873014)

Name: Anti-Human ASIC1 Polyclonal Antibody
Brand: abinScience
SKU: HX873014
Price: 168 USD
Availability: InStock

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100ug

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HX873014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ASIC1 (His72-Tyr426).

Target

ASIC1, Amiloride-sensitive cation channel 2, neuronal, BNaC2, Brain sodium channel 2, ACCN2, Acid-sensing ion channel 1, BNAC2

Purification

Purified by antigen affinity column.

Accession

P78348

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Acid-sensing ion channel 1 (ASIC1) is a ~59 kDa protein. Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory. Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents. Displays high selectivity for sodium ions but can also permit the permeation of other cations. Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines. Modulates neuronal activity in the circuits underlying innate fear.

1. Hoagland, EN. et al. (2010) The Journal of biological chemistry 285, 41852-62. PMID: 21036899

2. Sun, D. et al. (2020) eLife 9. PMID: 32915133

3. Wu, Y. et al. (2021) eLife 10. PMID: 34319232

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Human ASIC1 polyclonal antibody at 1ug/mL on recombinant Human ASIC1 (Catalog No. HX873012).

References

Datasheet