

| Catalog No. | HT045014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human ATP2A1 (Thr357-Leu600). | ||||||||
| Target | ATP2A1, Calcium pump 1, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform, SERCA1, Endoplasmic reticulum class 1/2 Ca(2+) ATPase, SR Ca(2+)-ATPase 1 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | O14983 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1) is a ~110 kDa protein. Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. 1. Odermatt, A. et al. (2000) Human genetics 106, 482-91. PMID: 10914677 | ||||||||
| Note | For research use only. |
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