Anti-Human ATRX/RAD54L Monoclonal Antibody (1A571) (HC152015)

Name: Anti-Human ATRX/RAD54L Monoclonal Antibody (1A571)
Brand: abinScience
SKU: HC152015
Price: 106 USD
Availability: InStock

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Catalog No.	HC152015
Description	Anti-Human ATRX/RAD54L Monoclonal Antibody (1A571) [1A571] (HC152015) is a mouse monoclonal antibody detecting ATRX in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, IHC, WB
Host species	Mouse
Isotype	IgG
Clone ID	1A571
Clonality	Monoclonal
Immunogen	E. coli - derived recombinant human ATRX/RAD54L (Thr1534-Asp1916).
Target	Transcriptional regulator ATRX, EC:3.6.4.12, ATP-dependent helicase ATRX, X-linked helicase II, X-linked nuclear protein, XNP, Znf-HX, ATRX
Purification	Protein A/G purified from cell culture supernatant.
Accession	P46100
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Transcriptional regulator ATRX (RAD54L) is a ~282 kDa protein. Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. 1. Episkopou, H. et al. (2014) Nucleic acids research 42, 4391-405. PMID: 24500201 2. Valle-García, D. et al. (2016) Epigenetics 11, 398-414. PMID: 27029610
Note	For research use only.

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Anti-Human ATRX/RAD54L Monoclonal Antibody (1A571).pdf

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Anti-Human ATRX/RAD54L Monoclonal Antibody (1A571) (HC152015)

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