Anti-Human BAG3 Recombinant Antibody (SAA0529), APC (HF640137)

Name: Anti-Human BAG3 Recombinant Antibody (SAA0529), APC
Brand: abinScience
SKU: HF640137
Price: 214 USD
Availability: InStock

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Overview

Catalog No.	HF640137
Species reactivity	Human
Applications	ELISA, FCM
Host species	Human
Isotype	IgG2a, kappa
Clone ID	SAA0529
Conjugation	APC
Clonality	Monoclonal
Target	Docking protein CAIR-1, BAG3, Bcl-2-associated athanogene 3, BAG family molecular chaperone regulator 3, Bcl-2-binding protein Bis, BAG-3, BIS
Endotoxin level	Please contact with the lab for this information.
Accession	O95817
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	BAG family molecular chaperone regulator 3 (BAG3) is a ~61 kDa protein. Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release. Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD). 1. Rauch, JN. et al. (2017) Journal of molecular biology 429, 128-141. PMID: 27884606 2. Meister-Broekema, M. et al. (2018) Nature communications 9, 5342. PMID: 30559338 3. Rauch, JN. et al. (2016) The Journal of biological chemistry 291, 19848-57. PMID: 27474739 4. Takayama, S. et al. (1999) The Journal of biological chemistry 274, 781-6. PMID: 9873016 5. Lee, JH. et al. (1999) Oncogene 18, 6183-90. PMID: 10597216 6. Jin, YH. et al. (2015) Biochemical and biophysical research communications 464, 561-7. PMID: 26159920
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human BAG3 Recombinant Antibody (SAA0529), APC.pdf

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Anti-Human BAG3 Recombinant Antibody (SAA0529), APC (HF640137)

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