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Anti-Human BIRC6 Polyclonal Antibody (HV669014)

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Overview
Catalog No.HV669014
Description
Anti-Human BIRC6 Polyclonal Antibody (HV669014) is a rabbit polyclonal antibody detecting BIRC6. Suitable for Mouse and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human BIRC6 (Arg4576-Leu4857).
Target APOLLON, BIR repeat-containing ubiquitin-conjugating enzyme, BIRC6, BRUCE, Baculoviral IAP repeat-containing protein 6, Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6, EC:2.3.2.24, KIAA1289, Ubiquitin-conjugating BIR domain enzyme apollon
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q9NR09
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 is a ~530 kDa protein. Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase. Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide. Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6. Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent.

1. Qiu, XB. et al. (2004) The EMBO journal 23, 800-10. PMID: 14765125
2. Bartke, T. et al. (2004) Molecular cell 14, 801-11. PMID: 15200957
3. Pohl, C. et al. (2008) Cell 132, 832-45. PMID: 18329369
4. Hunkeler, M. et al. (2023) Science (New York, N.Y.) 379, 1105-1111. PMID: 36758104
5. Ehrmann, JF. et al. (2023) Science (New York, N.Y.) 379, 1117-1123. PMID: 36758105
6. Dietz, L. et al. (2023) Science (New York, N.Y.) 379, 1112-1117. PMID: 36758106
Note For research use only
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Datasheet
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Formula
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Anti-Human BIRC6 Polyclonal Antibody

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