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Anti-Human CALHM6 Polyclonal Antibody (HP586014)

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Overview
Catalog No.HP586014
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human CALHM6 (Arg197-Ile309).
Target C6orf187, FAM26F, Calcium homeostasis modulator protein 6, Protein FAM26F, CALHM6
Purification Purified by antigen affinity column.
Accession Q5R3K3
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Calcium homeostasis modulator protein 6 (CALHM6) is a ~34 kDa protein. Pore-forming subunit of an ATP-permeable channel. In response to pathogen-derived and proinflammatory stimuli, relocates from intracellular compartments to NK-dendritic cell and NK-macrophage immune synapses where it mediates ATP efflux and NK cell activation involved in antimicrobial and antitumor responses. May assemble to form gap junction channel-like structures with gating and ion conductance likely regulated by membrane lipids and voltage rather than by extracellular calcium levels.

1. Drożdżyk, K. et al. (2020) eLife 9. PMID: 32374262
Note For research use only.
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Formula
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V₁ (Stock Vol.)
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Anti-Human CALHM6 Polyclonal Antibody

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