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Anti-Human CASP9/Caspase 9 Monoclonal Antibody (1A127) (HX251025)

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Anti-Human CASP9/Caspase 9 Monoclonal Antibody (1A127)
Anti-Human CASP9/Caspase 9 Monoclonal Antibody (1A127)
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Overview
Catalog No.HX251025
Description
Anti-Human CASP9/Caspase 9 Monoclonal Antibody (1A127) [1A127] (HX251025) is a mouse monoclonal antibody detecting Caspase-9 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Recombinant — Superior batch-to-batch reproducibility with defined sequences.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesMouse
ClonalityMonoclonal
IsotypeIgG1
Clone ID1A127
Immunogen E. coli - derived recombinant Human CASP9 / Caspase 9 (Lys100-Thr270).
Target CASP9, ICE-like apoptotic protease 6, Apoptotic protease Mch-6, APAF-3, CASP-9, MCH6, Apoptotic protease-activating factor 3, Caspase-9, ICE-LAP6,
Endotoxin level Please contact with the lab for this information.
Purity >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession P55211
Form Liquid
Storage buffer 0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Caspase-9 (CASP9/Caspase 9) is a ~46 kDa protein. Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC.

1. Ehrmann, JF. et al. (2023) Science (New York, N.Y.) 379, 1117-1123. PMID: 36758105
2. Dietz, L. et al. (2023) Science (New York, N.Y.) 379, 1112-1117. PMID: 36758106
Note For research use only.
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    SDS-PAGE

    SDS-PAGE for Anti-Human CASP9/Caspase 9 Monoclonal Antibody (1A127)

References
Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human CASP9/Caspase 9 Monoclonal Antibody (1A127)

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