Anti-Human CASQ1 Polyclonal Antibody (HB643014)

Name: Anti-Human CASQ1 Polyclonal Antibody
Brand: abinScience
SKU: HB643014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
SDS

Overview

Catalog No.

HB643014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CASQ1 (Asn56-Asp396).

Target

Calsequestrin, skeletal muscle isoform, CASQ, Calmitine, CASQ1, Calsequestrin-1

Purification

Purified by antigen affinity column.

Accession

P31415

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Calsequestrin-1 (CASQ1) is a ~45 kDa protein. Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity.

1. Barone, V. et al. (2017) Human mutation 38, 1761-1773. PMID: 28895244

2. Zhang, L. et al. (2016) Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 38, 2183-93. PMID: 27185316

Note

For research use only.

Images

References

Datasheet

Anti-Human CASQ1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human CASQ1 Polyclonal Antibody (HB643014)

Overview

Images

References

Datasheet

SDS

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