Anti-Human M-CSF R/CD115 Recombinant Antibody (FPA-008), PE (HY035127)

Name: Anti-Human M-CSF R/CD115 Recombinant Antibody (FPA-008), PE
Brand: abinScience
SKU: HY035127
Price: 290 USD
Availability: InStock

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Overview
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Datasheet
SDS

Overview

Catalog No.	HY035127
Species reactivity	Human
Applications	FCM
Host species	Human
Isotype	IgG4, kappa
Clone ID	FPA-008
Conjugation	PE
Clonality	Monoclonal
Tested applications	FCM
Target	CD115, CSF-1 receptor, CSF1R, M-CSF-R, CSF-1-R, Proto-oncogene c-Fms, Macrophage colony-stimulating factor 1 receptor, CSF-1R, FMS
Endotoxin level	Please contact with the lab for this information.
Associated products	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), PE
Accession	P07333
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Macrophage colony-stimulating factor 1 receptor (CD115/CSF1R) is a ~107 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. 1. Wei, S. et al. (2010) Journal of leukocyte biology 88, 495-505. PMID: 20504948 2. Guo, L. et al. (2019) American journal of human genetics 104, 925-935. PMID: 30982609 3. Oosterhof, N. et al. (2019) American journal of human genetics 104, 936-947. PMID: 30982608
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

Images

Flow CytoMetry

Flow-cytometry using PE anti-human CD115 antibody. THP-1 cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human CD115 monoclonal antibody (Catalog: HY035127, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.

References

Datasheet