Anti-Human IL-4R alpha Recombinant Antibody (SAA0046) (HB732107)

Name: Anti-Human IL-4R alpha Recombinant Antibody (SAA0046)
Brand: abinScience
SKU: HB732107
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HB732107
Description	Anti-Human IL-4R alpha Recombinant Antibody (SAA0046) (HB732107) is a human monoclonal antibody detecting IL-4R alpha in FCM. Suitable for Human. Highlights ●Affinity Purified — Minimal background and high purity for reliable results.
Species reactivity	Human
Applications	FCM
Host species	Human
Clonality	Monoclonal
Isotype	IgG4, kappa
Clone ID	SAA0046
Target	CD124, IL-4 receptor subunit alpha, IL-4-binding protein, IL-4R subunit alpha, IL-4R-alpha, IL-4RA, IL4-BP, IL4R, IL4RA, Interleukin-4 receptor subunit alpha, Soluble IL-4 receptor subunit alpha, Soluble IL-4R-alpha, Soluble interleukin-4 receptor subunit alpha, sIL4Ralpha/prot
Endotoxin level	< 10 EU/mg as determined by LAL method.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P24394
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Interleukin-4 receptor subunit alpha (CD124/IL4R) is a ~89 kDa protein. Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. CD124 is the therapeutic target of dupilumab (Dupixent). 1. Andrews, AL. et al. (2006) The Journal of allergy and clinical immunology 118, 858-65. PMID: 17030238
Note	For research use only.

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SDS-PAGE for Anti-Human CD124/IL4R Antibody (SAA0046)

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Datasheet

Anti-Human IL-4R alpha Recombinant Antibody (SAA0046).pdf

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Anti-Human IL-4R alpha Recombinant Antibody (SAA0046) (HB732107)

Overview

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References

Datasheet

SDS