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Anti-Human Flt-3/Flk-2 Recombinant Antibody (P5F7) (HW794107)

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Anti-Human Flt-3/Flk-2 Recombinant Antibody (P5F7)

Anti-Human Flt-3/Flk-2 Recombinant Antibody (P5F7)

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Overview

Catalog No.	HW794107
Description	Anti-Human CD135/FLT3 Antibody (P5F7) [P5F7] (HW794107) is a mouse monoclonal antibody detecting CD135 in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	P5F7
Clonality	Monoclonal
Target	FLT3, Stem cell tyrosine kinase 1, Fetal liver kinase-2, STK-1, STK1, FLK2, CD135, Receptor-type tyrosine-protein kinase FLT3, Fms-like tyrosine kinase 3, FL cytokine receptor, FLK-2, FLT-3
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P36888
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Receptor-type tyrosine-protein kinase FLT3 (CD135) is a ~112 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B.
Note	For research use only.

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Bioactivity

Detects CD135/FLT3 in indirect ELISAs.

References

Datasheet

Anti-Human Flt-3/Flk-2 Recombinant Antibody (P5F7).pdf

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Anti-Human Flt-3/Flk-2 Recombinant Antibody (P5F7)