Anti-Human CD141/THBD Polyclonal Antibody (HY397014)

Name: Anti-Human CD141/THBD Polyclonal Antibody
Brand: abinScience
SKU: HY397014
Price: 168 USD
Availability: InStock

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Overview
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References
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SDS

Overview

Catalog No.

HY397014

Description

Anti-Human CD141/THBD Polyclonal Antibody (HY397014) is a rabbit polyclonal antibody detecting CD141 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD141/THBD (Ala19-Asp486).

Target

THBD, THRM, CD141, Thrombomodulin, Fetomodulin, TM

Purification

Purified by antigen affinity column.

Accession

P07204

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Thrombomodulin (CD141/THBD) is a ~60 kDa protein. Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis. Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway. Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition. Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation. Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response.

1. Fuentes-Prior, P. et al. (2000) Nature 404, 518-25. PMID: 10761923

2. Daly, C. et al. (2018) Scientific reports 8, 505. PMID: 29323190

3. Giri, H. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 33836597

4. Dudek, AZ. et al. (1997) The Journal of biological chemistry 272, 31785-92. PMID: 9395524

5. Wu, C. et al. (2016) Journal of thrombosis and haemostasis : JTH 14, 366-74. PMID: 26663133

6. Abeyama, K. et al. (2005) The Journal of clinical investigation 115, 1267-74. PMID: 15841214

Note

For research use only.

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References

Datasheet