Anti-Human CD271/NGFR Monoclonal Antibody (1A634) (HY350025)

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Catalog No.	HY350025
Description	Anti-Human CD271/NGFR Monoclonal Antibody (1A634) [1A634] (HY350025) is a mouse monoclonal antibody detecting CD271 in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, IHC, WB
Host species	Mouse
Isotype	IgG
Clone ID	1A634
Clonality	Monoclonal
Immunogen	Mammalian cells - derived recombinant human CD271/NGFR (Met1-Asn250).
Target	Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, Low-affinity nerve growth factor receptor p75NGFR, Low-affinity nerve growth factor receptor p75NGR, p75 ICD, CD271, NGFR
Purification	Protein A/G purified from cell culture supernatant.
Accession	P08138
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Tumor necrosis factor receptor superfamily member 16 (CD271/NGFR) is a ~45 kDa protein. Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF. Plays an important role in differentiation and survival of specific neuronal populations during development. Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA. 1. Glerup, S. et al. (2014) Neuron 82, 1074-87. PMID: 24908487 2. Lin, Z. et al. (2015) eLife 4, e11692. PMID: 26646181 3. Baeza-Raja, B. et al. (2013) The Journal of neuroscience : the official journal of the Society for Neuroscience 33, 10221-34. PMID: 23785138 4. Li, H. et al. (2012) Science China. Life sciences 55, 367-74. PMID: 22566094
Note	For research use only.

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Anti-Human CD271/NGFR Monoclonal Antibody (1A634).pdf

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Anti-Human CD271/NGFR Monoclonal Antibody (1A634) (HY350025)

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