Anti-Human CD275/ICOSLG Recombinant Antibody (SAA0089), PerCP (HF564147)

Name: Anti-Human CD275/ICOSLG Recombinant Antibody (SAA0089), PerCP
Brand: abinScience
SKU: HF564147
Price: 268 USD
Availability: InStock

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Overview

Catalog No.	HF564147
Species reactivity	Human
Applications	FCM
Host species	Human
Isotype	IgG2, kappa
Clone ID	SAA0089
Conjugation	PerCP
Clonality	Monoclonal
Target	B7RP1, B7-related protein 1, CD275, ICOSL, ICOSLG, KIAA0653, B7 homolog 2, ICOS ligand, B7RP-1, B7H2, B7-H2, B7-like protein Gl50
Endotoxin level	Please contact with the lab for this information.
Associated products	Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10), PerCP
Accession	O75144
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	ICOS ligand (CD275/ICOSLG) is a ~33 kDa protein. Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion. Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP). 1. Yoshinaga, SK. et al. (2000) International immunology 12, 1439-47. PMID: 11007762 2. Wang, S. et al. (2000) Blood 96, 2808-13. PMID: 11023515 3. Roussel, L. et al. (2018) The Journal of experimental medicine 215, 3151-3164. PMID: 30498080
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.