Anti-Human CD314/KLRK1 Recombinant Antibody (SAA0098), FITC (HB123117)

Name: Anti-Human CD314/KLRK1 Recombinant Antibody (SAA0098), FITC
Brand: abinScience
SKU: HB123117
Price: 163 USD
Availability: InStock

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Overview

Catalog No.	HB123117
Species reactivity	Human
Applications	FCM
Host species	Human
Isotype	IgG4, kappa
Clone ID	SAA0098
Conjugation	FITC
Clonality	Monoclonal
Target	KLRK1, NKG2D, Killer cell lectin-like receptor subfamily K member 1, NKG2-D-activating NK receptor, D12S2489E, NKG2-D type II integral membrane protein, NK cell receptor D, CD314
Endotoxin level	Please contact with the lab for this information.
Associated products	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), FITC
Accession	P26718
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	NKG2-D type II integral membrane protein (CD314/KLRK1) is a ~25 kDa protein. Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF.
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.