Anti-Human TIM-3 Recombinant Antibody (TSR-022), PE (HV029127)

Name: Anti-Human TIM-3 Recombinant Antibody (TSR-022), PE
Brand: abinScience
SKU: HV029127
Price: 290 USD
Availability: InStock

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Overview

Catalog No.	HV029127
Species reactivity	Human
Applications	FCM
Host species	Human
Isotype	IgG4, kappa
Clone ID	TSR-022
Conjugation	PE
Clonality	Monoclonal
Target	T-cell immunoglobulin mucin receptor 3, HAVcr-2, TIMD-3, T-cell membrane protein 3, HAVCR2, Hepatitis A virus cellular receptor 2, CD366, TIMD3, TIM-3, TIM3, T-cell immunoglobulin and mucin domain-containing protein 3
Endotoxin level	Please contact with the lab for this information.
Associated products	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), PE
Accession	Q8TDQ0
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Hepatitis A virus cellular receptor 2 (CD366/TIM-3) is a ~33 kDa protein. Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. _x005F_x000D_ _x005F_x000D_ 1. Gorman, JV. et al. (2014) Immunologic research 59, 56-65. PMID: 24825777 _x005F_x000D_ _x005F_x000D_ 2. Monney, L. et al. (2002) Nature 415, 536-41. PMID: 11823861 _x005F_x000D_ _x005F_x000D_ 3. Sánchez-Fueyo, A. et al. (2003) Nature immunology 4, 1093-101. PMID: 14556005 _x005F_x000D_ _x005F_x000D_ 4. Clayton, KL. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 782-91. PMID: 24337741 _x005F_x000D_ _x005F_x000D_ 5. Tomkowicz, B. et al. (2015) PloS one 10, e0140694. PMID: 26492563 _x005F_x000D_ _x005F_x000D_ 6. Gautron, AS. et al. (2014) European journal of immunology 44, 2703-2711. PMID: 24838857 _x005F_x000D_ _x005F_x000D_ 7. Zhu, C. et al. (2005) Nature immunology 6, 1245-52. PMID: 16286920 _x005F_x000D_ _x005F_x000D_ 8. Leitner, J. et al. (2013) PLoS pathogens 9, e1003253. PMID: 23555261 _x005F_x000D_ _x005F_x000D_ 9. Gleason, MK. et al. (2012) Blood 119, 3064-72. PMID: 22323453
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.