Anti-Human CD37 Recombinant Antibody (SAA2107) (HY564013)

Name: Anti-Human CD37 Recombinant Antibody (SAA2107)
Brand: abinScience
SKU: HY564013
Price: 126 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HY564013

Species reactivity

Human

Applications

ELISA

Host species

Human

Isotype

IgG1, kappa

Clone ID

SAA2107

Clonality

Monoclonal

Target

Leukocyte antigen CD37, Tetraspanin-26, Tspan-26, CD37, CD37, TSPAN26

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P11049

RRID

Anti-Human CD37/TSPAN26 Antibody (SAA2107) (abinScience Cat# HY564013, RRID:AB_3729394)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Leukocyte antigen CD37 (TSPAN26) is a ~31 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B. Plays an essential role essential for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT.

1. Lapalombella, R. et al. (2012) Cancer cell 21, 694-708. PMID: 22624718

2. de Winde, CM. et al. (2016) The Journal of clinical investigation 126, 653-66. PMID: 26784544

3. Meyer-Wentrup, F. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 178, 154-62. PMID: 17182550

Note

For research use only.

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