Anti-Human Integrin alpha V/CD51 Recombinant Antibody (17E6#) (HY065107)

Name: Anti-Human Integrin alpha V/CD51 Recombinant Antibody (17E6#)
Brand: abinScience
SKU: HY065107
Price: 196 USD
Availability: InStock

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Overview

Catalog No.	HY065107
Species reactivity	Human
Applications	ELISA, FCM, IP, SPR, WB
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	17E6#
Clonality	Monoclonal
Target	MSK8, VNRA, Vitronectin receptor, Integrin alpha-V, Vitronectin receptor subunit alpha, CD51, ITGAV, VTNR
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P06756
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Integrin alpha-V (CD51/ITGAV) is a ~116 kDa protein. The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. 1. Fujita, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 5809-19. PMID: 23125415 2. Ieguchi, K. et al. (2010) The Journal of biological chemistry 285, 31388-98. PMID: 20682778 3. Mori, S. et al. (2008) The Journal of biological chemistry 283, 18066-75. PMID: 18441324 4. Mori, S. et al. (2017) Bioscience reports 37. PMID: 28302677 5. Saegusa, J. et al. (2009) The Journal of biological chemistry 284, 24106-14. PMID: 19578119 6. Cedano Prieto, DM. et al. (2017) PloS one 12, e0184285. PMID: 28873464 7. Takada, YK. et al. (2017) The Journal of biological chemistry 292, 20067-20075. PMID: 29030430 8. Saegusa, J. et al. (2008) The Journal of biological chemistry 283, 26107-15. PMID: 18635536 9. Fujita, M. et al. (2015) The Journal of biological chemistry 290, 259-71. PMID: 25398877 10. Bax, DV. et al. (2003) The Journal of biological chemistry 278, 34605-16. PMID: 12807887
Note	For research use only.

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Flow Cytometry

Flow-cytometry using anti-human CD51 antibody.CD51 Transfected CHO cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD51 antibody monoclonal antibody (Catalog # HY065107 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.

References

Datasheet