

| Catalog No. | HY036013 | ||||||
|---|---|---|---|---|---|---|---|
| Description |
Anti-Human CD71/TFRC Nanobody (SAA1205) [SAA1205] (HY036013) is a alpaca monoclonal antibody detecting CD71 in ELISA, FCM, WB. Suitable for Human.
Highlights
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| Species reactivity | Human | ||||||
| Applications | ELISA, FCM, WB | ||||||
| Host species | Alpaca | ||||||
| Clonality | Monoclonal | ||||||
| Isotype | VHH-8His-Cys-tag | ||||||
| Clone ID | SAA1205 | ||||||
| Target | CD71, T9, TFRC, TR, TfR, TfR1, Transferrin receptor 1, Transferrin receptor protein 1, Transferrin receptor protein 1, serum form, Trfr, p90, sTfR | ||||||
| Endotoxin level | < 10 EU/mg as determined by LAL method. | ||||||
| Purity | >95% as determined by SDS-PAGE. | ||||||
| Purification | Purified by Nickel column. | ||||||
| Accession | P02786 | ||||||
| Form | Liquid | ||||||
| Storage buffer | 0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||
| Background | Transferrin receptor protein 1 (CD71/TFRC & IDS) is a ~84 kDa protein. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. 1. Senyilmaz, D. et al. (2015) Nature 525, 124-8. PMID: 26214738 2. Jabara, HH. et al. (2016) Nature genetics 48, 74-8. PMID: 26642240 | ||||||
| Note | For research use only. |

SDS-PAGE for Anti-Human CD71/TFRC Recombinant Nanobody (SAA1205)




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