Anti-Human CD93/C1qR Recombinant Antibody (SAA2252) (HV345013)

Name: Anti-Human CD93/C1qR Recombinant Antibody (SAA2252)
Brand: abinScience
SKU: HV345013
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HV345013

Species reactivity

Human

Applications

WB, IF, blocking

Host species

Mouse

Isotype

IgG

Clone ID

SAA2252

Clonality

Monoclonal

Target

CD93/C1qR

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9NPY3

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Complement component C1q receptor (CD93/C1qR) is a ~68 kDa protein. Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration.

1. Geertsma, MF. et al. (1994) The American journal of physiology 267, L578-84. PMID: 7977768

2. Orlandini, M. et al. (2014) Oncotarget 5, 2750-60. PMID: 24809468

3. Galvagni, F. et al. (2016) Oncotarget 7, 10090-103. PMID: 26848865

4. Khan, KA. et al. (2017) Oncogene 36, 6097-6108. PMID: 28671670

5. Barbera, S. et al. (2023) International journal of biological macromolecules 224, 453-464. PMID: 36265539

6. Xu, Y. et al. (2024) Structure (London, England : 1993) 32, 282-291.e4. PMID: 38218180

Note

For research use only.

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