Anti-Human CERS2 Polyclonal Antibody (HP591014)

Name: Anti-Human CERS2 Polyclonal Antibody
Brand: abinScience
SKU: HP591014
Price: 168 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HP591014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CERS2 (Asn81-Ser128).

Target

SP260, CERS2, LASS2, CerS2, TMSG1, Ceramide synthase 2, LAG1 longevity assurance homolog 2, Tumor metastasis-suppressor gene 1 protein, Sphingosine N-acyltransferase CERS2

Purification

Purified by antigen affinity column.

Accession

Q96G23

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Ceramide synthase 2 (CERS2) is a ~44 kDa protein. Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions.

1. Lahiri, S. et al. (2007) FEBS letters 581, 5289-94. PMID: 17977534

2. Laviad, EL. et al. (2008) The Journal of biological chemistry 283, 5677-84. PMID: 18165233

3. Mizutani, Y. et al. (2008) Journal of lipid research 49, 2356-64. PMID: 18541923

4. Spassieva, SD. et al. (2009) The Biochemical journal 424, 273-83. PMID: 19728861

5. Ohno, Y. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 18439-44. PMID: 20937905

6. Tidhar, R. et al. (2012) The Journal of biological chemistry 287, 3197-206. PMID: 22144673

7. Kim, HJ. et al. (2012) Journal of lipid research 53, 1701-7. PMID: 22661289

8. Sassa, T. et al. (2016) The Journal of biological chemistry 291, 7477-87. PMID: 26887952

9. Tidhar, R. et al. (2018) The Journal of biological chemistry 293, 9912-9921. PMID: 29632068

Note

For research use only.

Images

References

Datasheet

Anti-Human CERS2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-Human CERS2 Polyclonal Antibody (HP591014)

Overview

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References

Datasheet

SDS

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