Anti-Human CHRNA7 Recombinant Nanobody (SAA2795) (HW806013)

Name: Anti-Human CHRNA7 Recombinant Nanobody (SAA2795)
Brand: abinScience
SKU: HW806013
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HW806013
Description	Anti-Human CHRNA7 Nanobody (SAA2795) (HW806013) is a alpaca monoclonal antibody detecting CHRNA7. Suitable for Human.
Species reactivity	Human
Applications	ELISA
Host species	Alpaca
Isotype	VHH-His
Clone ID	SAA2795
Clonality	Monoclonal
Target	CHRNA7, NACHRA7, Neuronal acetylcholine receptor subunit alpha-7, Nicotinic acetylcholine receptor subunit alpha-7, nAChR7
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P36544
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7) is a ~56 kDa protein. Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA7 forms homopentameric neuronal acetylcholine receptors abundantly expressed in the central nervous system, characterized by fast desensitization and high calcium permeability. Also forms heteropentamers with CHRNB2, mainly expressed in basal forebrain cholinergic neurons. 1. Ellison, M. et al. (2004) Biochemistry 43, 16019-26. PMID: 15609996 2. Noviello, CM. et al. (2021) Cell 184, 2121-2134.e13. PMID: 33735609 3. Peng, X. et al. (1994) Molecular pharmacology 45, 546-54. PMID: 8145738 4. Nielsen, BE. et al. (2019) Neuropharmacology 160, 107794. PMID: 31560909 5. Burke, SM. et al. (2024) Cell 187, 1160-1176.e21. PMID: 38382524 6. George, AA. et al. (2021) The Journal of neuroscience : the official journal of the Society for Neuroscience 41, 555-575. PMID: 33239400 7. Wang, H. et al. (2003) Nature 421, 384-8. PMID: 12508119 8. Yoshikawa, H. et al. (2006) Clinical and experimental immunology 146, 116-23. PMID: 16968406
Note	For research use only

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Anti-Human CHRNA7 Recombinant Nanobody (SAA2795).pdf

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Anti-Human CHRNA7 Recombinant Nanobody (SAA2795) (HW806013)

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