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Anti-Human CHRNB4 Polyclonal Antibody (HB165014)

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Overview
Catalog No.HB165014
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human CHRNB4 (Arg22-Lys231).
Target CHRNB4, Neuronal acetylcholine receptor subunit beta-4
Purification Purified by antigen affinity column.
Accession P30926
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Neuronal acetylcholine receptor subunit beta-4 (CHRNB4) is a ~56 kDa protein. Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNB4 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3 and CHRNA4, as well as CHRNA5 and CHRNB3 as accesory subunits. CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor.

1. Kuryatov, A. et al. (2011) Molecular pharmacology 79, 119-25. PMID: 20881005
2. Gharpure, A. et al. (2019) Neuron 104, 501-511.e6. PMID: 31488329
3. Wang, F. et al. (1996) The Journal of biological chemistry 271, 17656-65. PMID: 8663494
4. Elliott, KJ. et al. (1996) Journal of molecular neuroscience : MN 7, 217-28. PMID: 8906617
5. Gerzanich, V. et al. (1997) Molecular pharmacology 51, 320-7. PMID: 9203638
6. Boorman, JP. et al. (2000) The Journal of physiology 529 Pt 3, 565-77. PMID: 11118490
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human CHRNB4 Polyclonal Antibody

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