Anti-Human CIAO2B Polyclonal Antibody (HP061014)

Name: Anti-Human CIAO2B Polyclonal Antibody
Brand: abinScience
SKU: HP061014
Price: 168 USD
Availability: InStock

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References
Datasheet
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Overview

Catalog No.

HP061014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CIAO2B (Thr29-Ser163).

Target

Mitotic spindle-associated MMXD complex subunit MIP18, FAM96B, Protein FAM96B, MSS19-interacting protein of 18 kDa, CIAB, CIAO2B, MIP18, Cytosolic iron-sulfur assembly component 2B

Purification

Purified by antigen affinity column.

Accession

Q9Y3D0

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Cytosolic iron-sulfur assembly component 2B (CIAO2B) is a ~17 kDa protein. Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis.

1. Gari, K. et al. (2012) Science (New York, N.Y.) 337, 243-5. PMID: 22678361

2. Stehling, O. et al. (2012) Science (New York, N.Y.) 337, 195-9. PMID: 22678362

3. Stehling, O. et al. (2013) Cell metabolism 18, 187-98. PMID: 23891004

4. Ben-Shimon, L. et al. (2018) Journal of cell science 131. PMID: 29848660

5. Ito, S. et al. (2010) Molecular cell 39, 632-40. PMID: 20797633

Note

For research use only.

Images

References

Datasheet

Anti-Human CIAO2B Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human CIAO2B Polyclonal Antibody (HP061014)

Overview

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References

Datasheet

SDS

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