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Anti-Human CIITA Monoclonal Antibody (1A618) (HC153015)

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Anti-Human CIITA Monoclonal Antibody (1A618)
Anti-Human CIITA Monoclonal Antibody (1A618)
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Overview
Catalog No.HC153015
Description
Anti-Human CIITA Monoclonal Antibody (1A618) [1A618] (HC153015) is a mouse monoclonal antibody detecting CIITA in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Recombinant — Superior batch-to-batch reproducibility with defined sequences.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesMouse
IsotypeIgG
Clone ID1A618
Clonality Monoclonal
Immunogen E. coli - derived recombinant human CIITA (Arg886-Arg1130).
Target MHC class II transactivator, CIITA, EC:2.3.1.-, EC:2.7.11.1, CIITA
Purification Protein A/G purified from cell culture supernatant.
Accession P33076
Form Liquid
Storage buffer 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

MHC class II transactivator (CIITA) is a ~123 kDa protein. Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. Does not bind DNA. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984,. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes.

1. Al-Kandari, W. et al. (2007) Molecular immunology 44, 311-21. PMID: 16600381
2. Al-Kandari, W. et al. (2007) Journal of molecular biology 369, 1175-87. PMID: 17493635
3. Riley, JL. et al. (1995) Immunity 2, 533-43. PMID: 7749984
4. Steimle, V. et al. (1993) Cell 75, 135-46. PMID: 8402893
5. Maassen, F. et al. (2025) eLife 14. PMID: 40608405
Note For research use only.
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    SDS-PAGE for Anti-Human CIITA Monoclonal Antibody (1A618)

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Datasheet
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Formula
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Anti-Human CIITA Monoclonal Antibody (1A618)

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