Anti-Human CLEC6A/Dectin-2 Recombinant Antibody (BDC-3042) (HA366023)

Name: Anti-Human CLEC6A/Dectin-2 Recombinant Antibody (BDC-3042)
Brand: abinScience
SKU: HA366023
Price: 191 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HA366023

Species reactivity

Human

Applications

ELISA, FACS, Functional assay

Host species

Human

Isotype

IgG1, kappa

Clone ID

BDC-3042

Clonality

Monoclonal

Target

C-type lectin domain family 6 member A, C-type lectin superfamily member 10, CLEC6A, CLECSF10, DC-associated C-type lectin 2, DECTIN2, Dectin-2, Dendritic cell-associated C-type lectin 2

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q6EIG7

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

C-type lectin domain family 6 member A (CLEC6A/Dectin-2) is a ~23 kDa protein. Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses.

1. Zhu, LL. et al. (2013) Immunity 39, 324-34. PMID: 23911656

2. Feinberg, H. et al. (2017) The Journal of biological chemistry 292, 13402-13414. PMID: 28652405

Note

For research use only

Images

SDS-PAGE

SDS-PAGE for Anti-Human CLEC6A/Dectin-2 Antibody (BDC-3042)

References

Datasheet

Anti-Human CLEC6A/Dectin-2 Recombinant Antibody (BDC-3042).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human CLEC6A/Dectin-2 Recombinant Antibody (BDC-3042) (HA366023)

Overview

Images

References

Datasheet

SDS

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