Anti-Human CMPK2 Polyclonal Antibody (HA833014)

Name: Anti-Human CMPK2 Polyclonal Antibody
Brand: abinScience
SKU: HA833014
Price: 96 USD
Availability: InStock

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Overview
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Datasheet
SDS

Overview

Catalog No.

HA833014

Description

Anti-Human CMPK2 Polyclonal Antibody (HA833014) is a rabbit polyclonal antibody detecting mitochondrial; 2.7.4.14; Nucleoside-diphosphate kinase; 2.7.4.6; CMPK2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant human CMPK2 (Leu99-Pro449).

Target

UMP-CMP kinase 2, mitochondrial; 2.7.4.14; Nucleoside-diphosphate kinase; 2.7.4.6; CMPK2

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q5EBM0

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

UMP-CMP kinase 2, mitochondrial (CMPK2) is a ~49 kDa protein. Mitochondrial nucleotide monophosphate kinase needed for salvage dNTP synthesis that mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways. Restricts the replication of multiple viruses including flaviviruses or coronaviruses. Together with viperin/RSAD2 and ddhCTP, suppresses the replication of several coronaviruses through inhibition of the viral RNA-dependent RNA polymerase activities. Concerning flaviviruses, restricts RNA translation when localized to the mitochondria independently of its kinase activity. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor.

1. Xu, Y. et al. (2008) The Journal of biological chemistry 283, 1563-1571. PMID: 17999954

2. El-Diwany, R. et al. (2018) Science advances 4, eaat0843. PMID: 30083606

3. Zhu, M. et al. (2023) PLoS biology 21, e3002039. PMID: 36930652

4. Pawlak, JB. et al. (2023) PLoS pathogens 19, e1011286. PMID: 37075076

Note

For research use only

Images

Western blot

Western blot analysis was performed using anti-CMPK2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Jurkat cell lysate

References

Datasheet

Anti-Human CMPK2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human CMPK2 Polyclonal Antibody (HA833014)

Overview

Images

References

Datasheet

SDS

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