Anti-Human CMTM6 Recombinant Nanobody (SAA2685) (HD496013)

Name: Anti-Human CMTM6 Recombinant Nanobody (SAA2685)
Brand: abinScience
SKU: HD496013
Price: 191 USD
Availability: InStock

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Catalog No.	HD496013
Description	Anti-Human CMTM6 Nanobody (SAA2685) [SAA2685] (HD496013) is a alpaca monoclonal antibody detecting CMTM6 in ELISA. Suitable for Human.
Species reactivity	Human
Applications	ELISA
Host species	Alpaca
Clonality	Monoclonal
Isotype	VHH-8His
Clone ID	SAA2685
Target	CKLF-like MARVEL transmembrane domain-containing protein 6, CKLFSF6, CMTM6, Chemokine-like factor superfamily member 6
Endotoxin level	<10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9NX76
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) is a ~20 kDa protein. Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.
Note	For research use only

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Anti-Human CMTM6 Recombinant Nanobody (SAA2685).pdf

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Anti-Human CMTM6 Recombinant Nanobody (SAA2685) (HD496013)

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